Background
He obtained his PhD in 2014 at University of Montpellier 2, working on the development of salivary biomarkers to assess human exposure to Aedes mosquitoes bites under the supervision of Dr Franck Remoue from IRD in France. He later returned in Cameroon where he was appointed as Post-doctoral fellow at Centre Pasteur du Cameroun in the framework of a multidisciplinary project funded by the Global funds. This project is aimed at developing, validating and disseminating a multidisciplinary operational evaluation ‘tool box’ for the integrated fight against malaria. In 2016, thanks to a three (03) years project awarded by Wellcome Trust, Dr Elanga was recruited into Prof Charles Wondji’s team first at the Research Unit of the Liverpool School of Tropical Medicine based at OCEAC, later at Centre for Research in Infectious Diseases (CRID). This latter project aimed to assess the impact of insecticide resistance on the sialome composition of African major malaria vectors. In 2018 he was awarded by “The World Academy of Sciences (TWAS)” to study the impact of pyrethroids resistance mechanisms of on salivary glands proteins expression in An. funestus mosquito. Beyond being a Principal Investigator, he is also a Deputy Head of the Medical Entomology Department.
Research:
- Areas of interest:
Mosquitoes borne diseases, vector control, transmission risk, salivary proteins, biomarkers, insecticide resistance, malaria, arboviruses.
- Research – an overview of his research areas(s)
Dr Elanga Ndille research activities are mainly focused on the study mosquitoes’ salivary glands proteins expression and their potential use as biomarkers for assessing mosquitoes borne diseases transmission risk. More specifically, by studying the human response to mosquito salivary proteins, he is working on the development of salivary biomarkers of to assess human exposure to mosquito’s bites. This is done using immuno-proteomic approach (iTRAQ, 2D SDS-PAGE, peptide microarray, ELISA) combined with bioinformatics.
He is also interested on the study of the impact insecticide resistance could have on the expression of salivary glands proteins in malaria vectors at both transcriptional level (Rnaseq analyses) and proteomic level (SDS-PAGE, iTRAQ).
- Research Areas:
Malaria transmission and vector control
- PhD Students:
- Miss DJOUKWA NOUAGE Lynda, Université de Yaoundé 1.
- Mr BINYANG Achille, Université de Yaoundé 1.
Other relevant expertise, professional memberships, etc
- Lecturer at Protestant University of Central Africa
- Member Pan Africa Mosquito Control Association (PAMCA)
Publications
1. Emmanuel Elanga-Ndille, Lynda Nouage, Achille Binyang, Tatiane Assatse, Billy Tene-Fossog, Magellan Tchouakui, Daniel Nguete Nguiffo, Helen Irving, Cyrille Ndo, Parfait Awono-Ambene and Charles S. Wondji. Overexpression of Two Members of D7 Salivary Genes Family is Associated with Pyrethroid Resistance in the Malaria Vector Anopheles funestus s.s. but Not in Anopheles gambiae in Cameroon. Genes 2019, 10(3), 211; https://doi.org/10.3390/genes10030211.
2. Essangui E, Eboumbou Moukoko CE, Nguedia N, Tchokwansi M, Banlanjo U, Maloba F, Fogang B, Donkeu C, Biabi M, Cheteug G, Kemleu S, Elanga-Ndille E, Lehman L, Ayong L. Demographical, hematological and serological risk factors for Plasmodium falciparum gametocyte carriage in a high stable transmission zone in Cameroon. PLoS One. 2019 Apr 25;14(4):e0216133. doi: 10.1371/journal.pone.0216133. eCollection 2019.
3. Elanga-Ndille, E.; Nouage, L.; Ndo, C.; Binyang, A.; Assatse, T.; Nguiffo-Nguete, D.; Djonabaye, D.; Irving, H.; Tene-Fossog, B.; Wondji, C.S. The G119S Acetylcholinesterase (Ace-1) Target Site Mutation Confers Carbamate Resistance in the Major Malaria Vector Anopheles gambiae from Cameroon: A Challenge for the Coming IRS Implementation. Genes 2019, 10, 790.
4. Nouage L, Elanga-Ndille E, Binyang A, Tchouakui M, Atsatse T, Ndo C, et al. (2020) Influence of GST- and P450-based metabolic resistance to pyrethroids on blood feeding in the major African malaria vector Anopheles funestus. PLoS ONE 15(9): e0230984. https://doi.org/10.1371/journal.pone.0230984
Cheteug G, Elanga-Ndille E, Donkeu C, Ekoko W, Oloume M, Essangui E, Nwane P, NSango SE, Etang J, Wanji S, Ayong L, Eboumbou Moukoko CE. Preliminary validation of the use of IgG antibody response to Anopheles gSG6-p1 salivary peptide to assess human exposure to malaria vector bites in two endemic areas of Cameroon in Central Africa. PLoS One. 2020 Dec 31;15(12):e0242510. doi: 10.1371/journal.pone.0242510. PMID: 33382730
