Unless insecticide resistance is properly managed, the recent gains in reducing malaria transmission could be lost. Worrying cases of high resistance levels to insecticides are emerging in major malaria vectors leading to extensive loss of efficacy of Long Lasting Insecticidal Nets (LLINs) including PBO-pyrethroid nets. Such rise of insecticide resistance is now a major concern for National Malaria Control Program (NMCP). However, the effectiveness of LLINs against the resistant population of wild Anopheles mosquito remains poorly characterized in Cameroon. This study aims to investigate the performance of PBO-based and new generation nets against malaria vectors in the context of pyrethroid resistance using cone assay and experimental hut trials approach. This study will provide to NMCP keys informations on the efficacy of PBO-based and new nets against local malaria vectors.