Bill and Melinda Gates Foundation project 1 : Molecular markers for metabolic resistance to insecticides

In the major malaria vectors including An. funestus and An. gambiae metabolic mechanisms are driving resistance to most insecticides, including pyrethroids. But, contrary to target-site resistance such as knockdown resistance (kdr) for which DNA-based markers have been detected for more than two decades, until of recent, no DNA-based molecular assays were available to easily track…

Wellcome Trust Senior Renewal Fellowship project : Elucidating the complex evolution of insecticide resistance in the major malaria vector Anopheles funestus Africa-wide and its impact on control tools

Worrying cases of high resistance levels to insecticides are emerging in major malaria vectors such as Anopheles funestus leading to extensive loss of efficacy of Long Lasting Insecticidal Nets (LLINs) including PBO-pyrethroid nets. Unless such super-resistance is managed, recent gains in reducing malaria transmission could be lost with terrible consequences. Unfortunately, the molecular drivers of…

COMAL (Co-Infection Plasmodium Malariae)

COMAL (Co-Infection Plasmodium Malariae) This project aims to fully characterize the P. malariae parasites which is the least studied of the Plasmodium parasites and often reported as a benign malaria parasite due to the lack of data on this parasite. To fill this gap, Comal plans to determine the survival strategy of P. malariae through…