CRID awarded grant for the detection of molecular markers of insecticide resistance in malaria vectors.

The Centre for Research in Infectious Diseases (CRID) has been awarded a $3.7 million grant by the Bill and Melinda Gates Foundation for the detection of molecular markers of insecticide resistance in malaria vectors in collaboration with the Liverpool School of Tropical Medicine (LSTM).

The project which aims at developing fast and accurate tools for detecting resistance mechanisms in field caught mosquitoes is led by Prof Charles Wondji with a Cameroon-based team at the CRID and also a UK-based team at LSTM. As Prof Charles Wondji reveals, the goal is to detect the genetic variants driving resistance to main insecticide classes in malaria vectors to enable the design of field applicable diagnostic tools.

Efforts to reduce Malaria burden rely extensively on the control of mosquitoes using insecticides. However, insecticide resistance observed in mosquito species that transmit this disease, is currently threatening our ability to control malaria in Africa. To prolong the continued effectiveness of control methods, it is necessary to better understand how these mosquitoes acquire resistance to insecticides including novel ones that are gradually been approved by the World Health Organisation (WHO)’ Prof Charles Wondji reiterates.

Considering that, the current insecticide resistance status of malaria vectors is measured via bioassays, which is a labour-intensive method requiring the collection of hundreds of mosquitoes, rearing in insectary and testing on several replicates of adult mosquitoes, this new funding will be a leverage for Professor Wondji and his team. The team will leverage on their expertise and recent success in detecting first DNA markers of metabolic resistance in malaria mosquitoes to elucidate key mechanisms of resistance and develop simple assays to help detect and track the spread of resistance and assess their impact on control intervention and malaria transmission in this new project.

This project will be greatly supported by an excellent international collaboration between CRID and LSTM while working with other partners in Ghana, Cameroon and Uganda.

Photo: Malaria-carrying mosquito resting on a bed net due to resistance to insecticide


2nd TVCAG Annual Meeting to Hold in Cameroon

One year after its official launch, the Technical Vector Control Advisory Group (TVCAG) is set to bring together all country members for a second annual plenary meeting.

The convocation will be in Cameroon at Dajoll Hotel in Mbankomo, Yaoundé on March 25, 2020.

The TVCAG was instituted in the framework of a scientific project named “Partnership for Increasing the Impact of Vector Control” (PIIVeC) funded by the United Kingdom’s Global Challenge Research Fund (GCRF). This project is being carried out at the Centre for Research in Infectious Diseases (CRID) located in Yaounde in collaboration with the Ministry of Public Health and through a partnership with the Liverpool School of Tropical Medicine (LSTM) United Kingdom.

The purpose of this second annual meeting is to;

  • Assess progress made in the control of vector borne diseases;
  • Share findings and evidences generated by projects launched under PIIVeC including Operational Research Projects;
  • Formulate recommendations to improve the control of vector borne diseases and;
  • Identify priorities and research topics for the second round of Operational Research Projects.

The TVCAG is a national technical working group tasked to bring togther all stakeholders directly or indirectly involved in the control of vector-borne diseases in Cameroon. Its mission is to fuel the Ministry of Public Health and other authorities incharge of health with informed advice on effective tools, strategies and interventions for vector control through regular assessment of research outputs.